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The ToxCastDB database has been created and added to the EPA's ACToR database. One purpose of the ToxCast database is to link biological, metabolic and cellular pathway data to gene and in vitro assay data for the chemicals screened in the ToxCast HTS assays. Also included in ToxCastDB are human disease and species homology information, which correlate with ToxCast assays that affect specific genetic loci. This information is designed to make it possible to infer the types of human disease associated with exposure to these chemicals.
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Heat map of 624 assay measurements (including multiple time points where available) in ToxCast phase I data set. Assays are arranged left to right, and chemicals are arranged top to bottom. The color bar at the top indicates the assay type: red (cell-free HTS), violet (multiplexed transcription reporter), yellow (biologically multiplexed activity profiling), green (high-content cell imaging), blue (multiplexed gene expression), pink (cell-based HTS), black (phase I and II XME cytotoxicity), white (real-time cell electronic sensing), and orange (HTS genotoxicity). Data values are -log10(AC50/LEC), where light pink is inactive and darker reds indicate increased activity (lower AC50/LEC).

Current Database: toxminer_v17

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