ToxCast Data Use Considerations

  • The activity of a chemical in a specific assay does not necessarily mean that it will cause toxicity or an adverse health outcome. There are many factors that determine whether a chemical will cause a specific adverse health outcome. Careful review is required to determine the use of the data in a particular decision context.
  • Interpretation of ToxCast data is expected to change over time as both the science and analytical methods improve.

Stakeholder Opportunities to Learn & Explore the Data

To get the best possible experience using the CSS Dashboard application we recommend using Mozilla Firefox or Google Chrome.

EPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration.

The iCSS Dashboard contains the results from more than 800 Assay Endpoints (High-Throughput Screening-HTS Data) across over 1,800 chemicals from seven primary HTS assay sources. The release of the iCSS Dashboard coincides with the release of the ToxCast Phase II data. All of the ToxCast Phase II data (including assay summary activity files, assay description files, effect and endpoint data files from animal toxicity studies, concentration response data files & chemical library and structure files) are available on the ToxCast Data Download Page.

Users of the iCSS Dashboard v0.5 can perform basic data and chemical selection, as well as simple data exploration in a seamless environment. EPA will continuously add functionality and improve overall usability and performance. The initial release conveys the conceptual framework and design of the iCSS web application.

Please email the Dashboards Team to provide feedback on ways to improve the Dashboard or to be added to a mailing list to receive status updates. The intent is to use stakeholder feedback to develop updated versions of the iCSS Dashboard and to add more Dashboards.

The vision is for the Dashboard to evolve into an iCSS web application which will become the portal to access all EPA computational toxicology research data and studies including:

  • Rapid, automated (or in vitro high-throughput) chemical screening data generated by the EPA’s Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration.
  • Aggregated public sources of chemical toxicity data (AcTOR).
  • Animal toxicity studies (ToxRefDB). Chemical exposure data and prediction models (ExpoCastDB).
  • High quality chemical structures and annotations (DSSTox).