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ToxRefDB was developed by the National Center for Computational Toxicology (NCCT) in partnership with EPA's Office of Pesticide Programs (OPP), to store data from in vivo animal toxicity studies. The database:

  • Contains pesticide registration toxicity data that used to be stored as hard-copy and scanned documents by OPP.
  • Currently includes chronic, cancer, sub-chronic, developmental, and reproductive studies on hundreds of chemicals (many are pesticide active ingredients).
  • Provides data that is accessible and computable.
  • Provides reference toxicity data for Agency research and retrospective analyses.
  • Provides toxicity endpoints for development of ToxCast predictive signatures that will be used for primary research applications.
  • Contains only certain hazard information and does not represent all information needed for a complete risk assessment for pesticides or other chemicals.
  • Effect designation should not be taken as determination that existing EPA risk assessments and risk management decisions need revisions. For example, in addition to studies in ToxRefDB, for purposes of registration or tolerance determination, EPA evaluated information on other mammalian toxicity effects, metabolism, aquatic life, wildlife and plant toxicity studies, and use patterns, environmental fate and persistence, and pesticide residue levels.

    • Links and results from three manuscripts covering chronic/cancer, multigeneration reproductive, and prenatal developmental studies and endpoints aggregation serve as a resource for predictive toxicology research are below.

    Data SetDescriptionDownloadPublication
    Data Entry Tool & Controlled VocabularyThe Data Entry Tool provided the user interface for all initial data input into ToxRefDB. The controlled vocabulary standardized the capturing of regulatory animal toxicity studies performed across various study types.
    (more info)
    Download
    (15.5 MB, ZIP)
    Martin et al. (2009)
    Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database
    Environmental Health Perspectives
    doi:10.1289/ehp.0800074
    Chronic & Cancer EndpointsBased on incidence, severity and potency, 26 primarily tissue-specific pathology endpoints were selected to uniformly classify 310 chemicals included in the manuscript's analysis. The chemical coverage for chronic & cancer endpoints has expanded to include greater than 330 chemicals.
    (more info)
    Download
    (2.7 MB, XLS)
    Martin et al. (2009)
    Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database
    Environmental Health Perspectives
    doi:10.1289/ehp.0800074
    Developmental Toxicity EndpointsBased on the results from prenatal developmental toxicity studies spanning more than 380 chemicals, 18 endpoints for both the rat and rabbit were derived through the aggregation of system-related developmental effects. Additionally, overall maternal and developmental lowest effect levels are provided.
    (more info)
    Download
    (498 KB, XLS)
    Knudsen et al. (2009)
    Profiling the Activity of Environmental Chemicals in Prenatal Developmental Toxicity Studies using the U.S. EPA's ToxRefDB
    Reproductive Toxicology
    doi:10.1016/j.reprotox.2009.03.016
    Reproductive Toxicity EndpointsResults from multigeneration reproductive toxicity studies on 316 chemicals: 19 parental, reproductive and offspring endpoints were selected for ToxCast predictive modeling; 6 chemical groups with similar profiles of reproductive toxicity were identified for comparison to in vitro biological activity.
    (more info)
    Download #1
    (74 KB, XLS)
    Download #2
    (1.52 MB, XLS)
    Martin et al. (2009)
    Profiling the Reproductive Toxicity of Chemicals from Multigeneration Studies in the Toxicity Reference Database (ToxRefDB)
    Toxicological Sciences
    doi:10.1093/toxsci/kfp080
    ToxRefDB data can be downloaded from ACToR/ToxRefDB Download
    Summary Statistics
    Study Count 1978
    Chemical Count 474
    Chronic Cancer Rat 324
    Chronic Cancer Mouse 324
    Multigeneration Reproductive Rat 352
    Prenatal Developmental Rat 365
    Prenatal Developmental Rabbit 331
    Subchronic Rodent 302
    Current Database: toxrefdb_2010q1b

    Disclaimer: Results presented on effects, exposure or other values are dependent on both the source data and analysis methods used. Designations of effects, exposure or other values by the EPA Office of Research and Development does not represent an official Agency determination or policy relevant to priority, hazard, exposure or risk of a particular chemical or material.

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